Abilify Generic

Aripiprazole is an anti-psychotic drug for treating psychoses. Like other anti-psychotic drugs the mechanism of action of aripiprazole is unknown. Moreover like other anti-psychotics it blocks several receptors on the nerves of the brain for several neurotransmitters chemicals that nerves use to communicate with each other. It is thought that its beneficial effect is due to its effects on dopamine and serotonin receptors. Its effects on these receptors are complex involving stimulation of the receptors but to a lesser degree than the naturally-occurring neurotransmitters a process called partial agonism. The FDA approved aripiprazole as a treatment for schizophrenia in November of 2002.

Aripiprazole usually is taken once a day. The usual starting dose is 10 or 15 mg once daily. The dose may be increased over time to achieve the desired effect. Aripiprazole can be taken with or without food

Some of the most common side effects associated with aripiprazole are anxiety blurred vision constipation cough headache insomnia light-headedness nausea rash restlessness runny nose sleepiness tremors vomiting weakness and weight gain. As with other anti-psychotics long-term use of aripiprazole may lead to a potentially irreversible condition called tardive dyskinesia involuntary movements of the jaw lips and tongue. A potentially fatal complex referred to as neuroleptic malignant syndrome has been reported with anti-psychotic drugs including aripiprazole. Patients who develop this syndrome may have high fevers muscle rigidity altered mental status irregular pulse or blood pressure rapid heart rate excessive sweating and heart arrhythmias.

Although there is no clear link between aripiprazole and diabetes patients should be tested during treatment for elevated blood-sugars. Additionally persons with risk factors for diabetes including obesity or a family history of diabetes should have their fasting levels of blood sugar tested before starting treatment and periodically throughout treatment to detect the onset of diabetes. Any patient developing symptoms that suggest diabetes during treatment should be tested for diabetes.

Carbamazepine Tegretol can markedly decrease the amount of aripiprazole in the body by increasing the rate at which the bodys enzymes particularly the liver enzyme CYP3A4. degrade it. The manufacturer recommends that patients on aripiprazole who are started on carbamazepine double their dose of aripiprazole under their doctors supervision. Other drugs that can promote the activity of CYP3A4 and decrease the bodys levels of aripiprazole are phenytoin Dilantin rifampin and phenobarbital.

Ketoconazole Nizoral can increase the amount of aripiprazole in the body by blocking CYP3A4. The manufacturer of aripiprazole recommends reducing the dose of aripiprazole by one-half during ketoconazole therapy. Many other drugs also are known to block CYP3A4 and potentially could increase the levels of aripiprazole but their actual effects on aripiprazole levels have not been studied. Such drugs include: itraconazole Sporanox fluconazole Diflucan voriconazole Vfend cimetidine Tagamet verapamil Calan Isoptin diltiazem Cardizem Dilacor erythromycin clarithromycin Biaxin nefazodone Serzone ritonavir Norvir saquinavir Invirase nelfinavir Viracept indinavir Crixivan and grapefruit juice.

Quinidine inhibits another liver enzyme known as CYP2D6 that also breaks down aripiprazole and can increase the amount of aripiprazole in the body. The manufacturer of aripiprazole recommends reducing the dose of aripiprazole by one-half during quinidine therapy. Other medicines that block CYP2D6 include fluoxetine Prozac and paroxetine Paxil.

Alpha-1 receptor blockers doxazosin Cardura prazosin Minipress terazosin Hytrin used for control of blood pressure and prostatic enlargement may increase the chance of hypotension unusually low blood pressure.

Aripiprazole is used to treat severe mental disorders psychoses like schizophrenia which are characterized by distorted thoughts perceptions and emotions.

Tablets should be stored at room temperature 15-30°C 59-86°F

Before taking aripiprazole

tell your doctor and pharmacist if you are allergic to aripiprazole or any other medications.
tell your doctor and pharmacist what prescription and nonprescription medications vitamins nutritional supplements and herbal products you are taking. Be sure to mention any of the following: amiodarone Cordarone Pacerone antidepressants mood elevators antifungals such as fluconazole Diflucan itraconazole Sporanox and ketoconazole Nizoral antihistamines bupropion Wellbutrin carbamazepine Tegretol celecoxib Celebrex chlorpromazine Thorazine cimetidine Tagamet clarithromycin Biaxin clomipramine Anafranil cyclosporine Neoral Sandimmune danazol Danocrine delavirdine Rescriptor dexamethasone Decadron diltiazem Cardizem Dilacor Tiazac doxorubicin Adriamycin erythromycin E.E.S. E-Mycin Erythrocin ethosuximide Zarontin fluoxetine Prozac Sarafem fluvoxamine Luvox HIV protease inhibitors such as indinavir Crixivan and ritonavir Norvir ipratropium Atrovent isoniazid INH Nydrazid medications for anxiety blood pressure irritable bowel disease mental illness motion sickness Parkinsons disease seizures ulcers or urinary problems metoclopramide Reglan methadone Dolophine metronidazole Flagyl nefazodone Serzone oral contraceptives birth control pills paroxetine Paxil phenobarbital Luminal Solfoton phenytoin Dilantin primidone Mysoline quinidine Cardioquin Quinaglute Quinidex ranitidine Zantac rifabutin Mycobutin rifampin Rifadin Rimactane sedatives sertraline Zoloft sleeping pills terbinafine Lamisil tranquilizers troglitazone Rezulin troleandomycin TAO verapamil Calan Covera Isoptin Verelan and zafirlukast Accolate. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
tell your doctor if you have or have ever had heart disease heart failure high or low blood pressure a stroke a mini-stroke seizures Alzheimers disease any condition that makes it difficult for you to swallow or if you or anyone in your family has or has ever had diabetes. Also tell your doctor if you have ever had to stop taking a medication for mental illness because of severe side effects.
tell your doctor if you are pregnant or plan to become pregnant. If you become pregnant while taking aripiprazole call your doctor.
you should not breastfeed while taking aripiprazole.
if you are having surgery including dental surgery tell the doctor or dentist that you are taking aripiprazole.
you should know that aripiprazole may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.
remember that alcohol can add to the drowsiness caused by this medication.
you should know that you may have increases in your blood sugar hyperglycemia while you are taking this medication even if you do not already have diabetes. If you have schizophrenia a mental illness that causes disturbed or unusual thinking loss of interest in life and strong or inappropriate emotions you are more likely to develop diabetes than people who do not have schizophrenia and taking aripiprazole or similar medications may increase this risk. Tell your doctor immediately if you have any of the following symptoms while you are taking aripiprazole: extreme thirst frequent urination extreme hunger blurred vision or weakness.It is very important to call your doctor as soon as you have any of these symptoms because high blood sugar can cause more serious symptoms such as dry mouth upset stomach and vomiting shortness of breath breath that smells fruity or decreased consciousnessand may become life-threatening if it is not treated at an early stage.
you should know that aripiprazole may cause dizziness lightheadedness and fainting when you get up too quickly from a lying position. This is more common when you first start taking aripiprazole. To avoid this problem get out of bed slowly resting your feet on the floor for a few minutes before standing up.
you should know that aripiprazole may make it harder for your body to cool down when it gets very hot. Tell your doctor if you plan to do vigorous exercise or be exposed to extreme heat. Make sure to drink plenty of fluids.