Many people are the victims of the term ‘Cholesterol’, which is very harmful for the human body. To control this situation, Crestor i.e. Rosuvastatin medicine is available in the market, which is quite popular. Rosuvastatin is an oral drug for lowering blood cholesterol levels. It belongs to a class of drugs called HMG-CoA reductase inhibitors more commonly referred to as statins. Other drugs in this class include Simvastatin Zocor, Lovastatin Mevacor, Pravastatin Pravachol, Atorvastatin Lipitor and fluvastatin Lescol. These drugs reduce cholesterol levels by inhibiting HMG-CoA reductase an enzyme that produces cholesterol in the liver. Rosuvastatin and other statins lower blood total cholesterol as well as blood LDL cholesterol levels. LDL cholesterol is the bad type of cholesterol that increases the risk of coronary artery disease, atherosclerosis and heart attacks. Lowering LDL cholesterol levels slows the progression of coronary artery disease and may even reverse it. Statins also increase HDL cholesterol the good type of cholesterol and reduce triglycerides.

Scientists have discovered that in addition to atherosclerosis, inflammation of the coronary arteries may also contribute to the development of heart attacks. The presence of inflammation can be determined by measuring a chemical in the blood called highly sensitive C-reactive protein Hs-CRP. Moreover Hs-CRP can be used to predict the occurrence of heart attacks, strokes and death. Hs-CRP is in fact a better predictor of the risk for heart attacks than LDL cholesterol. Scientists have found that statins reduce the level of Hs-CRP in the body presumably by reducing inflammation in the coronary arteries and this may be another mechanism through which statins prevent heart attacks, strokes and death. More research needs to be conducted however to confirm the importance of inflammation and the mechanisms through which statins work.

Rosuvastatin was approved by the FDA in August 2003.

For the exact dosage of the medication, please consult your doctor. The dose may be increased over time to achieve the desired effect.
Usually, the starting dose for most adults is 5 mg once daily. The maximum dose is 40 mg daily and this dose should be reserved for patients who do not adequately respond to a 20 mg dose. Take it with a full glass of water regardless of food. After consuming the Crestor medication, avoid taking Antacids at least for two hours minimum.

For more information, please consult from your doctor and your pharmacists.

The most common side effects of Rosuvastatin are headache, weakness, nausea, vomiting, diarrhea, upset stomach, constipation, muscle pain etc. Some allergic reactions can also be seen such as, trouble in breathing, itching, swelling, rashes, severe dizziness. Some unusual side effects can also been seen and if you notice them, stop taking the Crestor medication and rush to your doctor. These symptoms may include, chest pain yellowing of eyes and skin, vomiting, stomach pain, nausea, cramping, muscle pain, fever, tenderness, weakness with fever or unusual tiredness etc.

The most serious side effects are liver failure, muscle breakdown i.e. Rhabdomyolysis and kidney failure. Liver failure caused by statins is very rare. More often statins cause increases in liver tests due to injury to the liver. The test levels usually return to normal with continued therapy, but if the level is over three times the upper limit of normal or baseline practitioners usually stop the statin. Periodic measurement of liver tests is recommended for all statins. For Rosuvastatin these tests should be obtained before therapy is started and twelve weeks after therapy is started when the dose is increased if there is a medical concern and periodically during prolonged treatment. Rhabdomyolysis is a very rare but serious side effect of statin therapy. When used alone the frequency of Rhabdomyolysis due to statins is less than one percent. Rhabdomyolysis is a process in which there is severe injury to muscles leading to severe pain and the release of muscle protein myoglobin into the blood. Myoglobin may cause kidney failure. To prevent the occurrence of Rhabdomyolysis patients taking statins who develop unexplained muscle pain weakness or tenderness should report the symptoms to their provider. Rosuvastatin may cause reversible increases in the amount of protein excreted by the kidneys and in some patients kidney failure has occurred as a result. This effect depends on the dose and occurs more often at the 40 mg dose.

Call your doctor if you have any of these unusual problems or some new problems arises, while taking this medication which may appear severe or persistent to you. Consult your doctor immediately and get treated accordingly.

Drug interactions can result in unwanted side effects or prevent a medicine from doing its job. So, keep an eye on what all medicines do you consume during the course.
When administered with cyclosporine the blood level of Rosuvastatin increases seven fold and this could increase the side effects of Rosuvastatin.

Rosuvastatin increases the action of the blood thinner warfarin and could increase the risk of bleeding from warfarin. Antacids reduce the absorption of Rosuvastatin and should be administered two hours after Rosuvastatin. The use of Rosuvastatin with nicotinic acid Gemfibrozil or other drugs that may cause liver or muscle injury and may increase the incidence of the muscle injury.

So, please consult your doctor and get more information on the interactions of the Crestor medication and take precautions accordingly. If you wish to discontinue this medication, please consult your doctor before doing so.

In case of overdose call your local poison control center at 1-800-222-1222.
If the suffering patient has collapsed or is not breathing call local emergency services at 911. Canadian residents should call their local poison control center directly.

Keep all appointments with your doctor during the complete course. And never allow anyone else take your medication unless they are prescribed by their doctors themselves. Also inform your doctor if you have been the victim of any serious and major diseases. Without consulting your doctor, please do not take any OTC medications on your own, as they may interact with the current medicine and produce some life threatening results. To obtain good results, take the medicine and also exercise during the course. Also take low fat diet and try to reduce your weight.

If you missed the dose, do take the medicine immediately provided that there is ample of time in between the next dose. However if it is almost time for the next dose skip the missed dose and continue your regular dosing schedule. Never double dose it to cope up with the missed dose. And in case, if you miss the two consecutive doses consult to your doctor or physician for guidance and continue further.

Rosuvastatin is used for the reduction of blood total cholesterol, HDL cholesterol and triglyceride levels and to increase good HDL cholesterol levels. Reducing cholesterol and triglycerides may help to prevent heart attacks and strokes. This medicine may also be used to treat other purposes, but be sure to confirm it from your doctor.

Crestor medication is sometimes prescribed for other uses also, so ask your doctor or pharmacist for more information.

Olanzapine tablets are stored at a prescribed temperature of 2-25°C and 36-77°F.
Keep the medicine in a light-resistant tight container and away from heat, dampness or direct light. Check Expiry date without fail. Keep all medicines away from women, newborns, children and pets. Moisture or Heat may cause the break down of the medicine. In any case, do not store the medicine in the bathroom. However, some manufacturers vary in their storage recommendations. Therefore storage conditions for each product should be clarified with your pharmacist. Dispose it safely the outdated medicines.

Following precautions must be taken during consuming generic Crestor:

1. Let your doctor know about your complete medical history, if you have or have ever had any severe diseases like heart problems, kidney disease, breast cancer, high or low blood pressure, diabetes, liver disease or any other major disease.

2. Tell your doctor that what prescription and nonprescription medications you are taking or even any OTC like nutritional supplements, vitamins, minerals, herbal products etc. that you may be intaking, because there is possibility that they may interact with the Crestor medication and reproduce harmful results.

3. Inform your doctor if you consume alcohol or any alcohol containing beverages. Avoid taking excessive amounts of alcohol during the course, as it can produce adverse effects on the liver.

4. If you have to undergo any surgery, major operation or any dental procedure, inform your surgeon, dentist or doctor, that you are taking Crestor medication.

5. Let your doctor or the physician know about your any kind allergies. They may be any food, medicine, particularly to Crestor or any composition allergy.

6. Do not share the Crestor with others unless they are prescribed by the doctor themselves. If the medicine is no longer in use or is outdated, discard it immediately after checking with your doctor or your pharmacist.

7. Rush to your doctor immediately, if you experience unexplained muscle pain, tenderness or weakness, especially if it is accompanied by unusual tiredness or fever. This is necessary as the medicine can have adverse effects on muscle can lead to serious kidney problems.

8. Do not discontinue medication on your own. Consult your doctor before doing so.

9. Keep the medication out of reach of newborns, children and pets.

10. Tell your doctor if you are pregnant, plan to become pregnant or are breast-feeding. If you conceive during the course, immediately inform your doctor because HMG-CoA reductase inhibitors may cause birth defects or other severe problems in the baby if taken during pregnancy.

11. Keep all the appointments with your doctor as the doctor may need to change the doses of your medications or monitor you carefully for side effects caused to you.

12. Have regular check up with your doctor to see if the medicine is working properly to lower your cholesterol and triglyceride levels and to decide if you should continue to take it or should stop it.