Indocin Generic DescriptionsIndomethacin is a nonsteroidal anti-inflammatory drug NSAID that reduces fever pain and inflammation. It is similar to ibuprofen Motrin and naproxen Naprosyn Aleve. Indomethacin works by reducing the production of prostaglandins. Prostaglandins are chemicals that the body uses to cause fever pain and inflammation. Indomethacin blocks the enzymes that make prostaglandins cyclooxygenase 1 and 2 and thereby reduces the levels of prostaglandins. As a result fever pain and inflammation are reduced. Indomethacin is available in a sustained slow release form Indocin-SR. Indomethacin was first approved by the FDA in January 1965.
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