Lipitor Generic

Atorvastatin is an oral drug that lowers the level of cholesterol in the blood. It belongs to a class of drugs referred to as statins which includes lovastatin Mevacor simvastatin Zocor fluvastatin Lescol and pravastatin Pravachol. All statins including atorvastatin prevent the production of cholesterol by the liver by blocking the enzyme that makes cholesterol HMGCoA reductase. They lower total blood cholesterol as well as LDL cholesterol levels. LDL cholesterol is believed to be the bad cholesterol that is primarily responsible for the development of coronary artery disease. Lowering LDL cholesterol levels retards progression and may even reverse coronary artery disease. Unlike the other drugs in this class atorvastatin also can reduce the concentration of triglycerides in the blood. High blood concentrations of triglycerides also have been associated with coronary artery disease. Atorvastatin was approved by the FDA in December of 1996.

Atorvastatin is prescribed once daily. Starting doses are 10-40 mg. daily. It may be taken with or without food and at any time of day.

Atorvastatin is generally well-tolerated and side effects are rare. Minor side effects include constipation diarrhea fatigue gas heartburn and headache. Atorvastatin should be used with caution in patients with alcohol or other liver diseases. Persistently abnormal liver tests during treatment are rare but may require discontinuation of the medication. Rare cases of muscle inflammation myositis and breakdown have been reported with other drugs in this class HMGCoA reductase antagonists and it is assumed that this side effect also may occur with atorvastatin. Muscle breakdown causes the release of muscle protein myoglobin into the blood and accumulation of the protein in the kidney tubules resulting in kidney failure.

As with other drugs in this class the risk of muscle breakdown see Side Effects below is increased when atorvastatin is given together with other medications such as cyclosporine Sandimmune gemfibrozil Lopid erythromycin and nicotinic acid.

Atorvastatin is used for the treatment of high cholesterol and triglyceride levels. High blood cholesterol is first treated with exercise weight loss and a diet low in cholesterol and saturated fats. When these measures fail to achieve enough cholesterol-lowering medications such as atorvastatin may be added. The National Cholesterol Education Program NCEP has published treatment guidelines for use of these medications. These treatment guidelines take into account the level of LDL cholesterol as well as the presence of other factors that increase the risk for coronary artery disease such as diabetes hypertension cigarette smoking low HDL cholesterol level and family history of early coronary heart disease. The effectiveness of atorvastatin in lowering cholesterol is dose related meaning that higher doses reduce cholesterol more. Blood cholesterol determinations are performed at regular intervals during treatment so that adjustments in doses can be made.

Tablets should be stored below or at room temperature
15-30°C 59-86°F.