Melalong is classified therapeutically as a depigmenting agent. Tretinoin is all trans retinoic acid formed from the oxidation of the aldehyde group of retinene to a carboxyl group. Tretinoin is classified as a keratolytic agent.

Hydroquinone is a melanocytotoxic chemical which is oxidized in melanocytes to produce highly toxic compounds such as quinones. These cytotoxic compounds are responsible for the destruction of pigment cells which result in skin depigmentation. However cells are capable of protecting themselves against cytotoxic agents by intracellular gluthathione GSH. This protection takes place under the enzymatic action of the detoxification enzyme gluthathione S- transferase GST which is responsible for the conjugation of toxic species to GSH.

Melalong should be applied preferably once daily in the evening. Duration of application would be decided by the physician depending upon the response.

Follow the exact dosage as prescribed by your health care professional.
Contact your paediatrician regarding the use of this medicine in children.

The adverse reactions reported are drying fissuring of paranasal and infraorbital areas erythema and stinging. Occasional hypersensitivity localized contact dermatitis may develop. If this occurs medication should be discontinued and the physician notified immediately.

Inform your doctor if you are allergic to the formulation of this medication or any other medication in any other form.

Inform your doctor about any other medication you may be taking in any other form.

In case of overdose call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing call local emergency services at 911.

bStrictly for external use only./b

Important to avoid contact with eye and mucous membranes.

Exposure to sunlight and UV light will cause repigmentation of bleached areas.

If you conceive whilst on a course with this medication inform your doctor immediately.

If you need to undergo any kind of surgery inform your doctor you are taking this medicine.

Inform your doctor if you are pregnant breast feeding or planning to conceive.

Do not double applications to make up for a missed application. Consult your health care professional about your missed application.

Melalong Cream is indicated for the gradual bleaching of hyperpigmented skin conditions such as cholasma melasma freckles senile lentigines and other unwanted areas of melanin hyperpigmentation.

Consult your health care professional for more information.

Store in a cool dark place.

Do not freeze.

Prior history of allergic reaction to hydroquinone and/or tretinoin. The safety of melalong during pregnancy and childrenunder 12 years of age has not been established.

Caution to be exercised when topical tretinoin and hydroquinone is administered to a nursing woman.