Sildenafil Citrate Generic DescriptionsSexual dysfunction is a problem which occurs at any phase of the sexual cycle which prevents the couple from experiencing sexual satisfaction. This leads to enormous distress. Although many people hesitate to discuss such topics it is very important to understand the fact - that these problems should be solved at the earlier stages of the dysfunction or it may be too late. Mostly men over 40 years experience more sexual problems mainly erectile dysfunction.
Sexual problems can arise because of physical or psychological problems or both. In physical cause it may be because of alcohol diabetes hormonal imbalance kidney or liver problems neurological problems etc. While in psychological cause it may be anxiety distress depression guilty feelings sex concerns or past sex failures. The reason may be anything but the fact is it should be treated to save millions of lives and their partners saving the mankind.
It has been estimated that impotence affects 140 million men worldwide. Over half of all men with impotence are thought to have some physical medical cause. The remainder are believed to have psychogenic causes of impotence. Medical causes of impotence include diabetes and circulatory neurological or urological conditions.
Penile erection is caused by the engorgement of the penis with blood. This engorgement occurs when the blood vessels delivering blood to the penis increase the delivery of blood and the blood vessels carrying blood away from the penis decrease the removal of blood. Under normal conditions sexual stimulation leads to the production and release of nitric oxide in the penis. Nitric oxide then activates the enzyme guanylate cyclase which causes the production of cyclic guanosine monophosphate cGMP. It is the cGMP that is primarily responsible for the erection by affecting the amount of blood that the blood vessels deliver and remove from the penis.
Sildenafil also reduces the pressure in the pulmonary artery in a serious condition called pulmonary arterial hypertension.
Sildenafil inhibits an enzyme called phosphodiesterase-5 PDE5 which destroys the cGMP. Thus sildenafil prevents the destruction of cGMP and allows cGMP to accumulate and persist longer. The longer cGMP persists the more prolonged the engorgement of the penis.
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